So sorry to hear, and good for you in recognizing the problem! My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. Use topical or a collar if you are concerned. Is due for another tablet but I have been holding off. I dont want to have to put my dog down but hes suffering. She has had tremors, very lethargic, drinking lots of water. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Hopefully yours will be lucky and return to normal. I am trying to remain confident that my poor girl will recover. I am SOOO angry! Vet gave her a shot which stopped it. Then gave me pills of prednisone for him to take 1 pill twice a day . Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. Never ever again with this med for him. I had to give him flea prevention because he goes to Daycare. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. Side effects with Simparica are not common. I want to thank everyone who posted I could not find enough information on other sites. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. UPDATE We had one normal day on Friday. He now cannot go in the car anymore. My sincere sympathies to those with horrendous seizure side effects. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. I must admit that I am pretty nervous about it, but we shall see. HELP!! However, the product has not been evaluated in breeding, pregnant, or lactating dogs. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. By Tuesday evening symptoms came back worse. I gave it to him later in the month which was followed by a neurological event (ataxia, wetting himself, disorientation, and tremors). She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. All medicines come with some potential risks and side effects, and pet owners should weigh the potential risks and benefits in consultation with a veterinarian. Gave it to my dog on Thursday night and Sat stools were soft. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. Then she started having tremors. Not sure what effects he will continue to have. He has trouble raising his leg to urinate. lola weighs about 9lbs. It has been one week and she has been acting very anxious since. Additionally, many tick-borne diseases can affect humans as well as pets. The only change I could think of he started taking Simparica about 4 months ago. Thank you for this. After a day one back leg started working and after six days the other one began to have feeling in it. I gave it to her then I looked at the box that said never tested on pregnant dogs . Now do you get the connection? I do know that she was a healthy and somewhat energetic 10 year old before the treatment. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). This can help with feelings of anxiety, stress, and fear." My 11 year old mini Aussie has been taking Simparica 1.5 years. What should I do? Did your dog pass away? Will never use again. Mine has tremors once in a while and now I know why! After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Omg, this is beyond awful and makes me so worried. I'm so upset. He would come out of it when I shook him, so I didn't think anything of it at the time. His motor skills have been affected and hes been losing weight even though he eats heartily. Any tips on how to flush it from her system ? He protected our livestock from coyotes for many years and I took good care of him. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. We were so upset - I vowed to never use oral flea treatment again. My 18 month old dog has had Sim Perica trio. We are beyond sad that this has happened to him and pray he makes a full recovery. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. I did and they said they are going to report it to the FDA. I am not giving him his dose this month and seeing what happens. The seizure has finally stopped and he seems to be sleeping peacefully. This stuff should be banned. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. She nearly died. Side effects in general, especially for Simparica Trio, are extremely rare. I am very worried I called the vet they said oops sorry they made a mistake. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. I only stumbled on the side effects of this drug via a post on a Spinone group. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. Work up from the neurologist shows all his tests came back negative. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. He has never acted like he was in pain. How can you give a dog a pesticide to ingest. moxidectin/imidacloprid and the percentage of Simparica- treated dogs with no live mites was 15%, 69%, 93%, 94%, 100% and 100% on days 30, 60, 90, 120, 150 and 180, respectively . I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. She's been given this dosage for over a year. (On Monday, she fell down several times in an hour. Which Type of Dog Fence Is Right For Your Pet? Don't trust your vet, do your own research. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! She falls when she runs and when going up and down stairs. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. The king cavalier bichon mix seems to be ok just not eating much if at all. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. The Simparica chewable is a poor choice for dogs with a history of prior seizures. Started in February and within a couple of weeks ears started twitching. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. She is absolutely miserable and we're hoping she makes it. It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks. Has started to stumble and sleeps 10 to 12 hours at a time. RELATED: Signs Your Dog Might Be Having a Seizure. He is pissing a lot and often and drinking a lot of water. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. Just hoping you can give me something good and tell me your dog recovered. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. Neurologist doesnt seem to really know if the effects are long term or not. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. Glad i held off on the free sample i was given! I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. after a few months of this i decided to go back to Sentinel and Bravecto. Im certain that its the simparica. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. Itching has decreased immensely. - she's had several episodes since then. I gave this to my #3. He has been on just Simparica with no problems. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. He does well on Simparica trio and also has the Lyme shot ? These are classic neurological symptoms, exactly what our Pickles had before she passed. She does have history of seizures. Thank you for this information. I took her home. Instead it has become a world of greed. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. If anyone has discovered what can help please let me know. However, the following side effects are seen in less than 1 dog in 10,000 . I'm so sorry. Im throwing away the remaining 5 pills and going back to a topical medicine. All antiparasitics for dogs lower the seizure threshold. Can you tell me if your dog is back to normal now?!?! May not be from this med but too strange to at least not think about it. Her Liver enzymes were also through the roof. If not, we had some success with symptom management using Prednisone. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. I am so sad to read what is happening to some pets. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. 2-6 days in vomiting here and there. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. Really? I also lost my dog due to simparia Trio. I give my dogs Simparica at the beginning of each month. Don't risk the well-being of your beloved dog just because something is more convenient. It comes as the first choice when prescribing a treatment due to its liver flavor. Even ones on tv, he is shaking for an hour. Both products are safe for dogs when administered according to the label directions. Im so worried Ive lost him forever and hell never recover. Vet said "cant be Simparica because he had 9 days ago". Barely eats, but is drinking lots of water. He also got that odd cough here and there that I read someone else mention. This medicine is making her shaky/tremor, anxious, and she is panting a ton. This is terrible. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. It seemed impossible that our boy could age years in literally 3 days. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. Best case scenario, he is able to come home, but we aren't there yet. And it looks like the liver and/or the kidney will not take it too. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. Luckily, Simparica Trio for dogs is considered fairly safe. how long do simparica trio side effects last Author: Published on: in what way did this ruling produce a fundamental change in the united states 21 septiembre, 2020 Published in: hicks family genealogy He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. My family saw it , I did not . Be aware! He has been barking a lot more than he used to. Today, he wouldn't eat or drink any water. No side effects. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. Weakness and staggering three weeks later of weeks ears started twitching lost him forever hell! 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