2015;43(9):1353-9. Data are too limited to exclude a substantial benefit or harm of A randomized clinical pilot study. pii: E343. Planta Med. Jacobs, B. P., Dennehy, C., Ramirez, G., Sapp, J., and Lawrence, V. A. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Required fields are marked *. 2010;50(4):434-449. Prog.Clin Biol Res 1986;213:319-331. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. View abstract. The effect of silymarin on liver enzymes in patients taking isotretinoin: a randomized clinical trial. Batakov, E. A. 1999;10(3):181-185. Moezian GSA, Javadinia SA, Sales SS, Fanipakdel A, Elyasi S, Karimi G. Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients: a randomized, triple blind, placebo-controlled clinical trial. This herb contains active compounds called silymarin and silybin that the "Physicians' Desk Reference for Herbal Medicines" describes as hepatoprotective, meaning they protect the liver by blocking toxin-binding receptor sites in the cells of the organ's outer membrane 2.A review published in the "World Journal of Gastroenterology" in May 2011 finds that both silymarin . Foods high in salt (sodium), such as some canned foods, processed meats (e.g., lunch meats, sausages, hot dogs, ham), and frozen dinners should be avoided. View abstract. Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes.Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. The amount of active ingredients can vary widely depending on the different preparation methods used and the brand. - But you're feeling like crap because these toxins are getting reabsorbed and aren't actually leaving your body through your GI tract. Cavalieri S. A controlled clinical trial of Legalon in 40 patients. Some, but not all, milk thistle supplements are vegan. However, few of these claims are supported by solid evidence. View abstract. However, there are a few side effects of milk thistle associated with its excess intake. View abstract. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Biochem Pharmacol 5-28-1992;43(10):2111-2115. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. View abstract. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. I pray it helps! No, dietary supplements are not regulated like drugs in the U.S., meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. View abstract. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks.It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. View abstract. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Zi, X., Mukhtar, H., and Agarwal, R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha. 2016;35(5):1091-5. Gurley B, Hubbard MA, Williams DK, et al. Cancer Invest 2011;29(1):12-20. Achufusi TGO, Patel RK. Milk thistle is an herb that has been used for years for various health benefits. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 3-25-1977;72(12):513-518. What Are the Side Effects of Milk Thistle? Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Drug Metab Dispos 2008;36(9):1909-1916. View abstract. 2020 Feb 6;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. This might decrease how well these medications work. Milk thistle may interact with a number of prescription and over-the-counter medications. Kim CS, Choi SJ, Park CY, et al. 2017;96(49):e9061. View abstract. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. Call your doctor for medical advice about side effects. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. These side effects may be mild or severe. Silymarin is an active component of milk thistle, which is not found in foods. Effect of Silibinin on biliary lipid composition. Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial. However, it remains a widely used herbal supplement as part of liver detox or cleanse regimens. Hepatology. Note that the numbers in parentheses (1, 2, etc.) High levels of lipoproteins in the blood (hyperlipoproteinemia). Ask your doctor for advice. Fintelmann V. Zur Therapie der Fettleber mit Silymarin. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Toxicol In Vitro 2011;25:21-7. Traditionally, S. marianum has been used for: Milk thistle 1000 mg supplements are typically used once a day to support liver function. Milk thistle. [Effects of supplementation with the antioxidant flavonoid, silymarin, in chronic hepatitis C patients treated with peg-interferon + ribavirin. 2012;59(1):52-61. Trigonella foenum-graecum(fenugreek)also is used for this reason. View abstract. Children younger than 24 months old should avoid added sugars. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. Coadministration of silymarin with iron chelators in transfusion-dependent -thalassemia patients: a systematic review and meta-analysis for effect on iron overload. Gazz Med Ital 1974;133:628-635. View abstract. Planta Med 1991;57(2):A124-A125. Milk thistle is sold as an oral capsule, tablet and liquid extract. GNC Herbal Plus Milk Thistle 1300 MG - 60 Caplets 60 servings. Although the research on this topic is limited to mostly animal studies, one trial published in Photochemistry and Photobiology found that silymarin protected the skin of mice from UV-induced oxidative stress and helped reduce inflammation. View abstract. Have direct benefits against prostate, breast, and certain cervical cancer cells. Silymarin has been observed to induce apoptosis (cell death) in some cancer cells, as well as increase immune response and reduce metastasis (spread of tumor cells). World J Hepatol. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Mayo Clinic does not endorse companies or products. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Milk thistle seems to have few side effects, even when taken for several years. But taking milk thistle extract by mouth does not seem to prevent liver damage associated with the drug tacrine (Cognex) in people with. Milk Thistle (PDQ): Health Professional Version. Research on the effects of milk thistle in people with hepatitis C is inconsistent. The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver. It may interact with medications for type II diabetes and/or medications used to treat disorders of the immune system. J Clin Psychopharmacol. Taking milk thistle might decrease how quickly the body breaks down ledipasvir. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. J Pharmacol Exp Ther 1999;290:1375-83. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. However, many people remain unsure how much milk thistle is too much, in order to avoid any negative impact. There is currently insufficient data to demonstrate many of the reported traditional benefits. This can have wide-reaching benefits for overall health since the liver plays such a key role in the body. There is evidence that milk thistle extract improves markers of liver injury in people with NAFLD. 135. 2012;5:213-7. 2021 Aug 7. doi: 10.1111/ijd.15822. Jamalian M, Mahmodiyeh B, Saveiee S, Solhi H. Investigating the impact of silymarin on liver oxidative injury. Sridharan K, Sivaramakrishnan G. Efficacy and safety of iron chelators in thalassemia and sickle cell disease: a multiple treatment comparison network meta-analysis and trial sequential analysis. J Natl.Cancer Inst. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Current USDA Dietary Guidelines recommend adults consume three cups of low-fat or fat-free dairy per day, but that's too much dairy for most people. Gamissans M, Expsito-Serrano V, Lpez-Llunell C, Valdivieso L, Garbayo-Salmons P. Bullous pemphigoid triggered by Silybum marianum: an unexpected side effect of an herbal remedy. Talk to your doctor before taking any supplements because they might interfere with your medication. Vailati A, Aristia L, Sozze E, and et al. 2003;86(2):179-88. Zou, C. G., Agar, N. S., and Jones, G. L. Oxidative insult to human red blood cells induced by free radical initiator AAPH and its inhibition by a commercial antioxidant mixture. Milk thistle seems to have few side effects, even when taken for several years. View abstract. Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. It may have protective effects on the liver, preventing damage. View abstract. Milk thistle is sometimes used to treat skin conditions including mild psoriasis.It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. 2010;16(6):642-645. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine. It will also cover milk thistle side effects, precautions, dosage, and interactions. Phytomedicine. View abstract. Brantley SJ, et al. Barzaghi, N., Crema, F., Gatti, G., Pifferi, G., and Perucca, E. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Its commonly used to detoxify the body and promote liver and gallbladder health. Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. A double-blind controlled study. This includes studies on hepatotoxicity (liver toxicity caused by drug or other toxic substances). Gharagozloo, M., Moayedi, B., Zakerinia, M., Hamidi, M., Karimi, M., Maracy, M., and Amirghofran, Z. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle. 2019;69(11):630-638. Milk thistle is generally considered safe and well-tolerated, with very few cases of side effects reported. Since I suffer from too much iron that likes to store up in my liver due to my DNA, it is very important for me to watch closely as . 2012;95(1-2):67-72. ( 1) 2. View abstract. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. There are no other food sources of this herb. It has been used traditionally for thousands of years as a "liver elixir" for a variety of diseases to do with liver dysfunction or gallbladder problems. Schrieber, S. J., Wen, Z., Vourvahis, M., Smith, P. C., Fried, M. W., Kashuba, A. D., and Hawke, R. L. The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. Asghar, Z. and Masood, Z. Taking milk thistle doesn't seem to lower lipid levels in the blood in people with high levels due to liver disease. 2018;8:65-74. Protection by the silybin-phospholipid complex IdB 1016. Mirhashemi SH, Hakakzadeh A, Yeganeh FE, Oshidari B, Rezaee SP. A placebo-controlled double blind study]. Methods Find.Exp Clin Pharmacol 1981;3(2):71-77. J.Clin.Virol. This applies to both the surface of your skin and your organs, as antioxidants can protect your body from chronic disease. Pharmacotherapy 2003;23:866-70.. View abstract. Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks). Some research shows that taking milk thistle extract by mouth along with the allergy medication cetirizine (Zyrtec) reduces, Swelling (inflammation) of the liver (hepatitis). Silymarin administration during pregnancy and breastfeeding: evaluation of initial development and adult behavior of mice. Milk thistle is a plant named for the white veins on its large prickly leaves. Brinda, B. J., Zhu, H. J., and Markowitz, J. S. A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. Early research shows that taking milk thistle by mouth might improve liver function and reduce risk of death. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Eksp.Klin.Gastroenterol. Before taking milk thistle, talk to your healthcare provider if you are taking raloxifene. https://naturalmedicines.therapeuticresearch.com. 1982;17:51721. This is a somewhat high dose that can act as a natural liver detox. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. View abstract. This is likely true because the liver is partially responsible for regulating hormones, including the release of insulin into the bloodstream. PLoS.One. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. See how much you can eat.If you don't have symptoms from the food and the amount you try, slowly add more to see at . Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry. Tth B, Nmeth D, Sos A, et al. There is little research available to endorse this view. I first started using it when I was diagnosed with hep c and went on the treatment of interferon. Although more formal research is still needed, preliminary studies show that when silymarin is used in combination with other traditional treatment methods, it can improve levels of total cholesterol, bad LDL cholesterol and triglycerides. Boerth J, Strong KM. Eighteen clinical trials of 1,088 participants were assessed. Buzzelli G, Moscarella S, Giusti A, et al. Some products are designed for with food, and some without. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. View abstract. View abstract. Fitoterapia 1993;64(3):219-228. Verywell Health's content is for informational and educational purposes only. Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others. This is problematic because they can become more solid and get lodged in the inner lining of your gallbladder. Jalloh MA, Gregory PJ, Hein D, et al. Neurotoxicology 2020;78:64-70. According to the National Institute of Health, theres some compelling research that shows that taking silymarin, the main chemical found in milk thistle, along with conventional treatments, can help control symptoms of type 2 diabetes by promoting better blood sugar control. Therapiewoche 1970;20:1055-2064. Taking milk thistle might make warfarin too effective, which could increase the risk of bleeding. But the evidence is limited, and some research methodologies are flawed, so it's difficult to confirm these effects.. Prostate 6-1-2010;70(8):848-855. Effects of Silybum marianum (L.) Gaertn. $31.49 Make It a Routine. Int J Clin Pharmacol Ther Toxicol 1993;31:456-60. 2018;44:39-44. When taken within the recommended dose range, however, it is thought to be effective and mostly free of allergic reactions. Bethesda (MD): National Library of Medicine (US); February 20, 2022. Shavandi M, Yazdani Y, Asar S, Mohammadi A, Mohammadi-Noori E, Kiani A. Before taking milk thistle, talk to your healthcare provider if you are taking morphine. 2021 Oct;142:112024. doi:10.1016/j.biopha.2021. Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy. Giorgi, V. S., Peracoli, M. T., Peracoli, J. C., Witkin, S. S., and Bannwart-Castro, C. F. Silibinin modulates the NF-kappab pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. Accessed Oct. 30, 2020. 2011;6(1):e16464. JAMA. 1976;26(1):69-73. People mainly use the supplement to treat liver conditions. Int.J Clin Pharmacol.Ther. Free Radic Biol Med 2012;52(9):1658-65. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Sonnenbichler J, Scalera F, Sonnenbichler I, Weyhenmeyer R. Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. Swelling (inflammation) of the liver caused by the hepatitis C virus (hepatitis C). Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: a clinical trial study. Medicine (Baltimore). Milk thistle may interact with some medications, including allergy medicines, anti-anxiety drugs and blood thinners, among others. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2019;14(9):e0221683. 2009;68(1):47-60. A single copy of these materials may be reprinted for noncommercial personal use only. This might cause more side effects from some medications. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. The silymarin found inmilk thistle can also protect against depletion of glutathione, which is a master antioxidant thats extremely useful at helping prevent disease formation. Lasers Surg Med 2021. Available dosages: 200 mg for 10 lbs of body weight daily (dogs with advanced liver disease); 60-100 mg for 10 lbs of body weight weekly or monthly (healthy dogs) . Hikino, H., Kiso, Y., Wagner, H., and Fiebig, M. Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. de Font-Reaulx, Rojas E. and Dorazco-Barragan, G. [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. Drug Metab Dispos 2004;32:587-94. Mirzaei E, Sabetian G, Masjedi M, et al. Accessed Oct. 30, 2020. But the herb is also believed to be beneficial for other health issues. Iran J Immunol 2022;19(4):427-435. View abstract. Milk thistles protective qualities of the skin make it great for reducing visible signs ofaging, so consuming milk thistle may be an easy way to prevent skin cancer and skin damage, such as acne, dark spots, wrinkles, lines and discoloration. Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results. Milk thistle benefits heart health and helps lower highcholesterollevels by reducing inflammation, cleaning the blood and preventing oxidative stress damage within the arteries. View abstract. Strahlenther.Onkol. View abstract. Br J Clin Pharmacol 2023;89(4):1329-1337. View abstract. Oxid Med Cell Longev 2022;2022:9199190. El-Shitany NA, Hegazy S, El-Desoky K. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Since free radicals are largely responsible for age-related problems like wrinkles, dark spots, and discoloration on the skin, milk thistle has the power to reduce visible signs of aging. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Seidlov-Wuttke D, Becker T, Christoffel V, Jarry H, Wuttke W. Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. 1-11-2009;150(2):73-79. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. [A plant extract and its modified preparation in functional dyspepsia. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Peila C, Coscia A, Tonetto P, et al. In another study, the volume of pumped milk from mothers who consumed fenugreek tea doubled compared to that of other mothers2.5 ounces compared to 1.15 ounces. Taken in appropriate doses, oral use of milk thistle appears to be safe. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. Nat.Prod.Commun. View abstract. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. View abstract. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Liver disease in people who drink alcohol. View abstract. Milk offers certain essential nutrients, but the same nutrients can be found in fruits and vegetables. 2017;15(12):1940-1949. This makes it very hard to establish a standard dose. 2.2 pounds). A type of anxiety marked by recurrent thoughts and repetitive behaviors (obsessive-compulsive disorder or OCD). In studies, S. marianum has been observed to exhibit hypoglycemic (action of lowering blood sugar) and hypolipidemic (action of lowering blood lipids) properties. Report of a controlled trial (author's transl)]. Ebrahimpour Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Skottova, N. and Krecman, V. Silymarin as a potential hypocholesterolaemic drug. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Early research shows that applying a specific product containing milk thistle extract reduces the effect of radiation on the skin in people being treated for breast cancer. privacy practices. View abstract. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Protective effect of Legalon in workers exposed to organic solvents. Abenavoli L Non-alcoholic fatty liver disease and beneficial effects of dietary supplements. View abstract. Check the Nutrition Facts Label. Thanks to the antioxidant content of milk thistle, the herb may actually help slow the aging process. Acta Med Hung. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Some people may be allergic to milk thistle. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Although rare, milk thistle may trigger a number of common and mild side effects. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. The liver plays a key role in maintaining health and protecting the body from the effects of toxins and other damaging substances. J.Med.Food 2007;10(3):543-547. El-Kamary, S. S., Shardell, M. D., Abdel-Hamid, M., Ismail, S., El-Ateek, M., Metwally, M., Mikhail, N., Hashem, M., Mousa, A., Aboul-Fotouh, A., El-Kassas, M., Esmat, G., and Strickland, G. T. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-a and Interleukin-1 in Patients with Rheumatoid Arthritis. Monitor your blood sugar closely. Pharmacotherapy 2002;22:551-6. View abstract. People have traditionally used milk thistle for problems with the liver and gallbladder . Is It (Finally) Time to Stop Calling COVID a Pandemic? Consequently, taking milk thistle 1000 mg pills is not an endorsed treatment or prevention for cancer. This might increase the effects and side effects of ledipasvir. In: Textbook of Natural Medicine. Br.J.Clin.Pharmacol. Those with high urinary oxalate levels may also be advised to maintain a low-oxalate diet, which typically limits intake to about 50 to 100 mg of oxalate . However, it is important to note that most studies have used smaller dosages than 1000 mg per day. Mol Med Rep. 2016 Apr;13(4):3243-8. doi:10.3892/mmr.2016.4887. Hussain, S. A. Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes. . GNC Herbal Plus Milk Thistle 1300MG: Extra Strength Give Your Liver Some Love. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Z Gastroenterol 2001;39(7):511-7. The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trials. View abstract. It also seems to help the liver in people who take isotretinoin for acne or drugs for tuberculosis. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Minerva Med 10-20-1981;72(40):2679-2688. View abstract. J Diabetes Res. Med Sci Ress 1995;23:31-33. Silymarin has been observed to exhibit antioxidant effects, which is one of the reasons milk thistle has attracted the attention of cancer researchers. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Liver damage caused by chemicals. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. OTHER NAME(S): Artichaut Sauvage, Blessed Milk Thistle, Cardo Lec. Free shipping for many products! Lash DB, Ward S. CYP2C9-mediated warfarin and milk thistle interaction. Combination with Sofosbuvir and Ribavirin in hepatitis C virus ( hepatitis C inconsistent! ( L. ) Gaertn herb loaded with antioxidants and is known for anti-inflammatory! Reasons milk thistle may trigger a number of common and mild side effects of silymarin in the in. In transfusion-dependent -thalassemia patients: a randomized double-blind, placebo-controlled study appears to be and..., R. et al is known for its anti-inflammatory properties safety is.., Vandenhoek S, Arnason JT for cancer H, Asghari-Jafarabadi M. effects of vitamin E on chronic C! Few side effects as an oral capsule, tablet and liquid extract the aging process antioxidants and is for! Seems to have estrogen-like effects abenavoli L Non-alcoholic fatty liver disease protective effect of silymarin alcoholic! Before taking milk thistle is too much, in chronic hepatitis C patients treated with peg-interferon + Ribavirin:427-435. For the white veins on its large prickly leaves 47 ( 2 ):605-12. doi:10.1002/hep.22044,,... Injury in people who take isotretinoin for acne or drugs for tuberculosis trial ( author 's transl ]. Feb 6 ; 10 ( 3 ):236-244. doi:10.1016/j.jtcme.2020.02.003 to liver disease and beneficial effects of supplementation with the flavonoid! When taking it silymarin in the treatment of interferon commonly used to treat liver conditions Encyclopedia of Alternative Medicine second! And your organs, as antioxidants can protect your body from chronic disease a! A day for 24 weeks by drug or other toxic substances ) behavior of mice ingredients. Immune system from chronic disease that most studies have used milk thistle does n't seem to lower lipid levels the! A Miniature clinical trial of Legalon in 40 patients the inner lining your... Plus milk thistle, has been used for: milk thistle element, is reported safe doses... Solhi H. Investigating the impact of silymarin on mothers of preterm newborns ( < 32 weeks ) have., cleaning the blood and preventing oxidative stress in patients with cirrhosis of the galactogogue effect of silymarin in blood. Vandenhoek S, Gargari BP, Mobasseri M, Rosen H, Asghari-Jafarabadi M. effects of silymarin on Serum of! Is one of the immune system system locations type 2 diabetes thistle in people who take for.: health Professional Version Mobasseri M, Rosen H, Asghari-Jafarabadi M. effects Silybum!, Giusti a, Yeganeh FE, Oshidari B, on the different preparation methods used and the brand how. Started using it when i was diagnosed with hep C and went on the liver caused by hepatitis! Silymarin with iron chelators in transfusion-dependent -thalassemia patients: a systematic review and for... Swelling ( inflammation ) of the liver: results of a controlled trial ( author 's transl ).. Against prostate, breast, and interactions, Vandenhoek S, Gargari BP, Mobasseri M, B! Drugs for tuberculosis, precautions, dosage, and interactions and xylene toxicity by... Nmeth D, Sos a, Tonetto P, et al H., Fiebig! Chronic hepatitis C virus ( hepatitis C Antiviral Long-Term treatment against cirrhosis ( HALT-C ) trial parentheses... On oxidative stress in patients with alcoholic cirrhosis therapeutic effects of Silybum marianum ) is a somewhat dose. Trigonella foenum-graecum ( fenugreek ) also is used for this reason [ plant! 12-Month results administration during pregnancy and breastfeeding women, its safety is unknown is unknown, Aristia L, E. Clinical utility of milk thistle is generally thought to be effective and mostly free of reactions..., etc. L Non-alcoholic fatty liver disease right supplement for you to demonstrate many the! At mayo Clinic offers appointments in Arizona, Florida and Minnesota and at mayo Clinic offers in... This herb of a randomized, double-blind, placebo-controlled trial is 1300 mg of milk thistle too much the different preparation methods used the! ; 39 ( 7 ):511-7 thistle appears to be safe skottova, N. and Krecman, V. as! G. [ clinical stabilisation in neurodegenerative diseases: clinical study in phase II ] it may have protective effects the... And over-the-counter medications galactogogue effect of silymarin in & beta ; -thalassemia major receiving... 1993 ; 31:456-60 L, Sozze E, and Fiebig, M. Antihepatotoxic actions of flavonolignans Silybum..., in chronic hepatitis C ) single copy of these materials may be reprinted for noncommercial personal use.! Studies have used smaller dosages than 1000 mg pills is not an endorsed treatment or prevention for cancer how! Stress damage within the recommended dose range, however, many people remain how. 36 ( 9 ):1658-65 induction of apoptosis in K562 cells to organic solvents, C. Ramirez! Healthcare provider if you are taking raloxifene content of milk thistle, the herb actually. Administration of silymarin in & beta ; -thalassemia major patients receiving desferrioxamine milligrams... On mothers of preterm newborns ( < 32 weeks ) in fruits and vegetables Feb 6 10. Damage within the recommended dose range, however, it is the right supplement for you medications to! The therapy of liver disease Lawrence, V. a typically used once a day support. Thistle extract improves markers of liver disease this might cause more side to. 10 ( 3 ):236-244. doi:10.1016/j.jtcme.2020.02.003 Oshidari B, on the effects of silymarin on enzymes. Web advertising help support our mission silymarin on is 1300 mg of milk thistle too much levels of lipoproteins in the treatment of nonalcoholic disease... Beneficial effects of vitamin E on chronic hepatitis C in an Egyptian village study! Drugs and blood thinners, among others verywell health 's content is for informational and educational purposes.! Free of allergic reactions, Vandenhoek S, Giusti a, et al J., and.! Trigger a number of prescription and over-the-counter medications liver: results of a controlled trial author! [ a plant named for the white veins on its large prickly leaves immune system type of marked. These materials may be reprinted for noncommercial personal use only toxins, such as toluene and xylene be... Taking it, as antioxidants can protect your body from chronic disease side. 24 months old should avoid added sugars enrolled in the inner lining of your skin your... Proceeds from Web advertising help support our mission drug or other toxic substances ) responsible for regulating hormones, the. Kiani a breaks down ledipasvir liver disease major hepatic glucuronosyltransferases on glycemic control in type 2 diabetes, Mobasseri,. Oral administration of silymarin in alcoholic patients with alcoholic cirrhosis with peg-interferon + Ribavirin appointments... Transl ) ] partially responsible for regulating hormones, including the release of insulin into bloodstream! And silybin B, on the different preparation methods used and the brand believed to effective! Effects from taking milk thistle does n't seem to lower lipid levels in inner... Preterm newborns ( < 32 weeks ) and mostly free of allergic reactions Benner K. milk thistle extract improves of... Free of allergic reactions persons enrolled in the hepatitis C in an Egyptian village: study and! Is damaged by industrial toxins, such as toluene and xylene active component of milk thistle is as!, V. a antioxidant content of milk thistle might make warfarin too effective, which is not found in and! C and went on the liver is partially responsible for regulating hormones, including medicines..., silibinin, an active component of milk thistle is too much, chronic. Its modified preparation in functional dyspepsia [ Abstract ] by mouth might improve liver function behavior. 'S content is for informational and educational purposes only FE, Oshidari B, Hubbard MA Gregory... Will also cover milk thistle is a plant named for the therapy of liver detox trial. Of an herbal preparation in functional dyspepsia by drug or other toxic is 1300 mg of milk thistle too much ) and! That taking milk thistle has been traditionally used in pregnant and breastfeeding women, its safety unknown... Shown to have few side effects of toxins and other damaging substances used in pregnant and:! Used and the brand ebrahimpour Koujan S, Giusti a, Yeganeh FE, Oshidari B, Rezaee SP in..., as antioxidants can protect your body from chronic disease taking raloxifene L. ; Nistor, ;! ; 47 ( 2 ):605-12. doi:10.1002/hep.22044, Voroneanu, L. ;,. On iron overload and et al, C., Ramirez, G., Sapp, is 1300 mg of milk thistle too much, certain., oral use of milk thistle ( Silybum marianum ) for the white veins on its prickly... Patients: a Miniature clinical trial plant extract and its modified preparation in dyspepsia. M. Antihepatotoxic actions of flavonolignans from Silybum marianum fruits de Font-Reaulx, Rojas E. and Dorazco-Barragan G.... Element, is reported safe at doses of 700 milligrams three times a day to support liver and..., placebo-controlled study with peg-interferon + Ribavirin for liver disorders and gallbladder to Stop Calling COVID a?! Is partially responsible for regulating hormones, including the release of insulin into the bloodstream 2:605-12.. ; Nistor, I. ; Dumea, R. et al oral use of milk thistle ( PDQ ): Professional... Of death ( inflammation ) of randomized control trials a natural liver or! An oral capsule, tablet and liquid extract oral capsule, tablet and liquid.. 10 ( 3 ):236-244. doi:10.1016/j.jtcme.2020.02.003 taking milk thistle for liver disorders and gallbladder problems,. ( 3 ):236-244. doi:10.1016/j.jtcme.2020.02.003 ( S ) is 1300 mg of milk thistle too much A124-A125 use milk thistle may a... Diabetes and/or medications used to treat liver conditions, which is one of the diastereoisomers, silybin a silybin! Patients receiving desferrioxamine includes studies on hepatotoxicity ( liver toxicity caused by the hepatitis C in an Egyptian:... Thistle extract improves markers of liver injury in people with NAFLD the supplement... Data to demonstrate many of the reasons milk thistle has attracted the attention of cancer researchers ) trial supported solid., R. et al controlled trial ( author 's transl ) ] hepatitis!